What happens to pressurization when pneumatics are closed?

When pneumatics are closed, the pressurization system loses its source of pneumatic pressure, which is crucial for its operation. The pressurization relies on a properly functioning pneumatic system to maintain cabin pressure and ensure a safe and comfortable environment for occupants. Without the pneumatic source, the pressurization cannot function as intended, leading to its inoperability. This condition can compromise safety parameters, prompting immediate attention to restore pneumatic functionality or implement emergency procedures as necessary. Therefore, the assertion that it becomes inoperative is accurate and reflects the critical role that pneumatic systems play in maintaining cabin pressurization.